Long-Term Evolution of SARS-CoV-2 in an Immunocompromised Patient with Non-Hodgkin Lymphoma-Reference-Cited by-同舟云学术

Long-Term Evolution of SARS-CoV-2 in an Immunocompromised Patient with Non-Hodgkin Lymphoma

Published:2021-08-25 Issue:4 Volume:6 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Borges Vítor¹^ORCID,Isidro Joana¹^ORCID,Cunha Mário²,Cochicho Daniela²,Martins Luís²,Banha Luís²,Figueiredo Margarida²,Rebelo Leonor²,Trindade Maria Céu³,Duarte Sílvia⁴,Vieira Luís⁴,Alves Maria João⁵,Costa Inês⁶,Guiomar Raquel⁶,Santos Madalena⁷,Cortê-Real Rita⁷,Dias André⁸,Póvoas Diana⁸,Cabo João⁸,Figueiredo Carlos⁸,Manata Maria José⁸,Maltez Fernando⁸,Gomes da Silva Maria³,Gomes João Paulo¹^ORCID

Affiliation:

1. Bioinformatics Unit, Department of Infectious Diseases, National Institute of Health Dr. Ricardo Jorge (INSA), Lisbon, Portugal

2. Clinical Pathology–Virology Lab, Instituto Português de Oncologia de Lisboa, Lisbon, Portugal

3. Serviço de Hematologia, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal

4. Innovation and Technology Unit, Department of Human Genetics, National Institute of Health Dr. Ricardo Jorge (INSA), Lisbon, Portugal

5. Centre for Vectors and Infectious Diseases Research, Department of Infectious Diseases, National Institute of Health Dr. Ricardo Jorge (INSA), Lisbon, Portugal

6. National Reference Laboratory for Influenza and other Respiratory Viruses, Department of Infectious Diseases, National Institute of Health Doutor Ricardo Jorge (INSA), Lisbon, Portugal

7. Laboratório de Biologia Molecular, Serviço de Patologia Clínica do CHULC, Lisbon, Portugal

8. Serviço de Doenças Infecciosas do Hospital de Curry Cabral-CHULC, Lisbon, Portugal

Abstract

Tracking the within-patient evolution of SARS-CoV-2 is key to understanding how this pandemic virus shapes its genome toward immune evasion and survival. In the present study, by monitoring a long-term COVID-19 immunocompromised patient, we observed the concurrent emergence of mutations potentially associated with immune evasion and/or enhanced transmission, mostly targeting the SARS-CoV-2 key host-interacting protein and antigen.

Funder

Fundação para a Ciência e Tecnologia and Agência de Investigação Clínica e Inovação Biomédica

COMPETE 2020

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00244-21

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