A Toxic Friend: Genotoxic and Mutagenic Activity of the Probiotic Strain Escherichia coli Nissle 1917-Reference-Cited by-同舟云学术

A Toxic Friend: Genotoxic and Mutagenic Activity of the Probiotic Strain Escherichia coli Nissle 1917

Published:2021-08-25 Issue:4 Volume:6 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Nougayrède Jean-Philippe¹^ORCID,Chagneau Camille V.¹^ORCID,Motta Jean-Paul¹^ORCID,Bossuet-Greif Nadège¹,Belloy Marcy¹,Taieb Frédéric¹,Gratadoux Jean-Jacques²,Thomas Muriel²,Langella Philippe²,Oswald Eric¹³^ORCID

Affiliation:

1. IRSD, INSERM, INRAE, Université de Toulouse, ENVT, Toulouse, France

2. Micalis, INRAE, Jouy-en-Josas, France

3. CHU Toulouse, Hôpital Purpan, Service de Bactériologie-Hygiène, Toulouse, France

Abstract

Nissle 1917 is sold as a probiotic and considered safe even though it has been known since 2006 that it harbors the genes for colibactin synthesis. Colibactin is a potent genotoxin that is now linked to causative mutations found in human colorectal cancer.

Funder

Institut National Du Cancer

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00624-21

Reference51 articles.

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