IMMUNO-COV v2.0: Development and Validation of a High-Throughput Clinical Assay for Measuring SARS-CoV-2-Neutralizing Antibody Titers

Author:

Vandergaast Rianna1ORCID,Carey Timothy1,Reiter Samantha1,Lathrum Chase1,Lech Patrycja1,Gnanadurai Clement1,Haselton Michelle1,Buehler Jason1,Narjari Riya1,Schnebeck Luke1,Roesler Anne1,Sevola Kara1,Suksanpaisan Lukkana1,Bexon Alice2,Naik Shruthi23,Brunton Bethany2,Weaver Scott C.456,Rafael Grace456,Tran Sheryl2,Baum Alina7,Kyratsous Christos A.7,Peng Kah Whye123,Russell Stephen J.123

Affiliation:

1. Imanis Life Sciences, Rochester, Minnesota, USA

2. Vyriad, Inc., Rochester, Minnesota, USA

3. Mayo Clinic Department of Molecular Medicine, Rochester, Minnesota, USA

4. World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, Texas, USA

5. Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, USA

6. Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA

7. Regeneron Pharmaceuticals Inc., Tarrytown, New York, USA

Abstract

Since its emergence at the end of 2019, SARS-CoV-2, the causative agent of COVID-19, has caused over 100 million infections and 2.4 million deaths worldwide. Recently, countries have begun administering approved COVID-19 vaccines, which elicit strong immune responses and prevent disease in most vaccinated individuals.

Funder

Regeneron Pharmaceuticals

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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