Outer Membrane Vesicles Protect Gram-Negative Bacteria against Host Defense Peptides-Reference-Cited by-同舟云学术

Outer Membrane Vesicles Protect Gram-Negative Bacteria against Host Defense Peptides

Published:2021-08-25 Issue:4 Volume:6 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Balhuizen Melanie D.¹^ORCID,van Dijk Albert¹,Jansen Jeroen W. A.²,van de Lest Chris H. A.²,Veldhuizen Edwin J. A.³^ORCID,Haagsman Henk P.¹^ORCID

Affiliation:

1. Section of Molecular Host Defence, Division of Infectious Diseases and Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

2. Section of Cell Biology, Metabolism and Cancer, Division of Infectious Diseases and Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

3. Section of Immunology, Division of Infectious Diseases and Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

Abstract

Antibiotic resistance is a pressing problem and estimated to be a leading cause of mortality by 2050. Antimicrobial peptides, also known as host defense peptides (HDPs), and HDP-derived antimicrobials have potent antimicrobial activity and high potential as alternatives to antibiotics due to low resistance development.

Funder

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00523-21

Reference47 articles.

1. Bacteria Fighting Back: How Pathogens Target and Subvert the Host Innate Immune System

2. Zhang L, Gallo RL. 2019. Antimicrobial peptides. Springer, Singapore.

3. The human cathelicidin LL-37 — A pore-forming antibacterial peptide and host-cell modulator