Development of a Recombinant Epsilon Toxoid Vaccine against Enterotoxemia and Its Use as a Combination Vaccine with Live Attenuated Sheep Pox Virus against Enterotoxemia and Sheep Pox-Reference-Cited by-同舟云学术

Development of a Recombinant Epsilon Toxoid Vaccine against Enterotoxemia and Its Use as a Combination Vaccine with Live Attenuated Sheep Pox Virus against Enterotoxemia and Sheep Pox

Published:2010-06 Issue:6 Volume:17 Page:1013-1016
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

Chandran Dev¹²,Naidu Sureddi Satyam¹²,Sugumar Parthasarathy¹²,Rani Gudavalli Sudha¹²,Vijayan Shahana Pallichera¹²,Mathur Deepika¹²,Garg Lalit C.¹²,Srinivasan Villuppanoor Alwar¹²

Affiliation:

1. Indian Immunologicals Limited, Rakshapuram, Gachibowli, Hyderabad, India

2. Gene Regulation Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India

Abstract

ABSTRACT Sheep pox and enterotoxemia are important diseases of sheep, and these diseases cause severe economic losses to sheep farmers. The present study was undertaken to evaluate the potential of formaldehyde-inactivated recombinant epsilon toxin as a vaccine candidate. The potency of the recombinant epsilon toxoid with aluminum hydroxide as an adjuvant in sheep was determined. Vaccinated sheep were protected against enterotoxemia, with potency values of >5 IU being protective. Further, the use of this construct in a combination vaccine against sheep pox resulted in the sheep being protected against both sheep pox and enterotoxemia.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CVI.00013-10

Reference27 articles.

1. Merck veterinary manual 2003

2. Arya, S. N., and D. K. Bhatia. 1992. Incidence of some livestock diseases in Tamil Nadu. Indian J. Anim. Res.26:41-43.

3. Baqar, S., L. A. Applebee, and A. L. Bourgeois. 1995. Immunogenicity and protective efficacy of a prototype Campylobacter killed whole-cell vaccine in mice. Infect. Immun.83:3731-3735.

4. Batty, I., and A. T. Glenny. 1947. Titration of Clostridium welchii epsilon-toxin and antitoxin. Br. J. Exp. Pathol.28:110-126.

5. Bhown, A. S., and A. F. S. A. Habeeb. 1977. Structural studies on epsilon-prototoxin of Clostridium perfringens type D. Localization of the site of tryptic scission necessary for activation to epsilon-toxin. Biochem. Biophys. Res. Commun.78:889-896.

Cited by 34 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A recombinant capripoxvirus expressing the F protein of peste des petits ruminants virus and the P12A3C of foot-and-mouth disease virus;BMC Veterinary Research;2023-01-21

2. A Recombinant Capripoxvirus Expressing the F Protein of Peste des Petits Ruminants Virus and the P12A3C of Foot-and-mouth Disease Virus;2022-08-17

3. Immunogenic and neutralization efficacy of recombinant perfringolysin O of Clostridium perfringens and its C-terminal receptor-binding domain in a murine model;Immunologic Research;2022-01-15

4. Recombinant unpurified rETX^H106P/ CTB-rETX^Y196E protects rabbits against Clostridium perfringens epsilon toxin;Journal of Veterinary Medical Science;2021

5. Prevalence, Genotypic and Phenotypic Characterization and Antibiotic Resistance Profile of Clostridium perfringens Type A and D Isolated from Feces of Sheep (Ovis aries) and Goats (Capra hircus) in Punjab, Pakistan;Toxins;2020-10-14