SCO-1, a Novel Plasmid-Mediated Class A β-Lactamase with Carbenicillinase Characteristics from Escherichia coli-Reference-Cited by-同舟云学术

SCO-1, a Novel Plasmid-Mediated Class A β-Lactamase with Carbenicillinase Characteristics from Escherichia coli

Published:2007-06 Issue:6 Volume:51 Page:2185-2188
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Papagiannitsis C. C.¹,Loli A.¹,Tzouvelekis L. S.²,Tzelepi E.¹,Arlet G.³,Miriagou V.¹

Affiliation:

1. Laboratory of Bacteriology, Institut Pasteur Hellenique

2. Department of Microbiology, School of Medicine, University of Athens, Athens, Greece

3. Laboratoire de Bacteriologie, UPRES EA 2392, UFR Saint-Antoine, Universite Paris VI, Paris, France

Abstract

ABSTRACT A novel class A β-lactamase (SCO-1) encoded by an 80-kb self-transferable plasmid from Escherichia coli is described. The interaction of SCO-1 with β-lactams was similar to that of the CARB-type enzymes. Also, SCO-1 exhibited a 51% amino acid sequence identity with the RTG subgroup of chromosomal carbenicillinases (RTG-1, CARB-5, and CARB-8).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01439-06

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