A single locus determines praziquantel response in <i>Schistosoma mansoni</i>-Reference-Cited by-同舟云学术

A single locus determines praziquantel response in Schistosoma mansoni

Published:2024-03-06 Issue:3 Volume:68 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Chevalier Frédéric D.¹^ORCID,Le Clec’h Winka¹^ORCID,Berriman Matthew²^ORCID,Anderson Timothy J.C.³^ORCID

Affiliation:

1. Host-Pathogen Interactions Program, Texas Biomedical Research Institute, San Antonio, Texas, USA

2. School of Infection and Immunity, University of Glasgow, Glasgow, UK

3. Disease Intervention and Prevention Program, Texas Biomedical Research Institute, San Antonio, Texas, USA

Abstract

ABSTRACT We previously performed a genome-wide association study (GWAS) to identify the genetic basis of praziquantel (PZQ) response in schistosomes, identifying two quantitative trait loci situated on chromosomes 2 and 3. We reanalyzed this GWAS using the latest (version 10) genome assembly showing that a single locus on chromosome 3, rather than two independent loci, determines drug response. These results reveal that PZQ response is monogenic and demonstrates the importance of high-quality genomic information.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01432-23

Reference10 articles.

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