Does Nasal Cocolonization by Methicillin-Resistant Coagulase-Negative Staphylococci and Methicillin-Susceptible Staphylococcus aureus Strains Occur Frequently Enough To Represent a Risk of False-Positive Methicillin-Resistant S. aureus Determinations by Molecular Methods?

Author:

Becker Karsten1,Pagnier Isabelle1,Schuhen Brigitte1,Wenzelburger Frauke2,Friedrich Alexander W.3,Kipp Frank1,Peters Georg1,von Eiff Christof1

Affiliation:

1. Institute of Medical Microbiology

2. Department of Thoracic and Cardiovascular Surgery

3. Institute for Hygiene, University Hospital of Münster, 48149 Münster, Germany

Abstract

ABSTRACT By analyzing the colonization of the anterior nares in cardiothoracic surgery patients on admission, nasal cocolonization by methicillin-susceptible Staphylococcus aureus and methicillin-resistant coagulase-negative staphylococci was detected in 8/235 (3.4%) specimens. Consequently, in a low-methicillin-resistant S. aureus (MRSA) setting, a molecular MRSA screening test targeting the mecA gene and an S. aureus -specific gene in parallel and applied directly to clinical specimens would be associated with an unacceptable positive predictive value of about 40%.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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