Neutralizing Antibody Responses Induced by HIV-1 Envelope Glycoprotein SOSIP Trimers Derived from Elite Neutralizers-Reference-Cited by-同舟云学术

Neutralizing Antibody Responses Induced by HIV-1 Envelope Glycoprotein SOSIP Trimers Derived from Elite Neutralizers

Published:2020-11-23 Issue:24 Volume:94 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Schorcht Anna¹^ORCID,van den Kerkhof Tom L. G. M.¹²,Cottrell Christopher A.³,Allen Joel D.⁴,Torres Jonathan L.³,Behrens Anna-Janina⁴,Schermer Edith E.¹,Burger Judith A.¹,de Taeye Steven W.¹,Torrents de la Peña Alba³,Bontjer Ilja¹,Gumbs Stephanie¹,Ozorowski Gabriel³^ORCID,LaBranche Celia C.⁵^ORCID,de Val Natalia³⁶,Yasmeen Anila⁷,Klasse Per Johan⁷,Montefiori David C.⁵,Moore John P.⁷^ORCID,Schuitemaker Hanneke⁸,Crispin Max⁴,van Gils Marit J.¹,Ward Andrew B.³^ORCID,Sanders Rogier W.¹⁷

Affiliation:

1. Department of Medical Microbiology, Amsterdam Infection & Immunity Institute (AI&II), Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands

2. Department of Experimental Immunology, Amsterdam Infection & Immunity Institute (AI&II), Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands

3. Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA

4. School of Biological Science, University of Southampton, Southampton, United Kingdom

5. Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA

6. Center for Molecular Microscopy, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick National Laboratory, Leidos Biomedical Research Inc., Frederick, Maryland, USA

7. Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, USA

8. Janssen Pharmaceuticals, Leiden, the Netherlands

Abstract

Elite neutralizers, i.e., individuals who developed unusually broad and potent neutralizing antibody responses, might serve as blueprints for HIV-1 vaccine design. Here, we studied the immunogenicity of native-like recombinant envelope glycoprotein (Env) trimers based on viral sequences from elite neutralizers. While immunization with single trimers from elite neutralization did not recapitulate the breadth and potency of neutralization observed in these infected individuals, a combination of three subtype B Env trimers from elite neutralizers resulted in some neutralization breadth within subtype B viruses. These results should guide future efforts to design vaccines to induce broadly neutralizing antibodies.

Funder

European Union's Horizon 2020

AMC Fellowship

NIH F31 Ruth L. Kirschstein Predoctoral Award

HHS | National Institutes of Health

amfAR, The Foundation for AIDS Research

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Achievement Rewards for College Scientists Foundation

Bill and Melinda Gates Foundation

Publisher

American Society for Microbiology

Subject