Affiliation:
1. Servicio de Microbiologı́a, Hospital Ramón y Cajal, 28034 Madrid,1 and
2. Servicio de Microbiologı́a, Hospital Insular, Las Palmas de Gran Canaria,2 Spain
Abstract
ABSTRACT
A clinical strain of
Escherichia coli
(Ec GCE) displayed resistance to cefoxitin, cefotetan, cefotaxime, and ceftazidime. Susceptibility was not restored by the addition of clavulanic acid. Two β-lactamases with apparent pIs of 5.4 and 6.4 were identified; the β-lactamase with a pI of 6.4 was transferred by conjugation and associated with a 40-kb plasmid. Analysis of the nucleotide sequence showed a new
ampC
β-lactamase gene that is closely related to those encoding the FOX-3, FOX-2, and FOX-1 β-lactamases but whose product has four novel amino acid mutations, at positions 11 (M→T), 43 (A→E), 233 (V→A), and 280 (Y→H). This first cephamycinase from Spain was named FOX-4.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
45 articles.
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