Artemisone and Artemiside Are Potent Panreactive Antimalarial Agents That Also Synergize Redox Imbalance in Plasmodium falciparum Transmissible Gametocyte Stages-Reference-Cited by-同舟云学术

Artemisone and Artemiside Are Potent Panreactive Antimalarial Agents That Also Synergize Redox Imbalance in Plasmodium falciparum Transmissible Gametocyte Stages

Published:2018-08 Issue:8 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Coertzen Dina¹^ORCID,Reader Janette¹,van der Watt Mariëtte¹,Nondaba Sindisiwe H.¹,Gibhard Liezl²^ORCID,Wiesner Lubbe²,Smith Peter²,D'Alessandro Sarah³,Taramelli Donatella³,Wong Ho Ning⁴,du Preez Jan L.⁴,Wu Ronald Wai Keung⁵,Birkholtz Lyn-Marie¹^ORCID,Haynes Richard K.⁴

Affiliation:

1. Department of Biochemistry, University of Pretoria Institute for Sustainable Malaria Control, University of Pretoria, Hatfield, South Africa

2. Division of Clinical Pharmacology, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Observatory, South Africa

3. Dipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB), Università degli Studi di Milano, Milan, Italy

4. Center of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa

5. Department of Chemistry, The Hong Kong University of Science and Technology, Kowloon, Hong Kong

Abstract

The emergence of resistance toward artemisinin combination therapies (ACTs) by the malaria parasite Plasmodium falciparum has the potential to severely compromise malaria control. Therefore, the development of new artemisinins in combination with new drugs that impart activities toward both intraerythrocytic proliferative asexual and transmissible gametocyte stages, in particular, those of resistant parasites, is urgently required.

Funder

South African National Research Foundation

South African Medical Research Council

Bill and Melinda Gates Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02214-17

Reference99 articles.

1. World Health Organization. 2016. WHO world malaria report 2016. World Health Organization, Geneva, Switzerland.