pfk13 -Independent Treatment Failure in Four Imported Cases of Plasmodium falciparum Malaria Treated with Artemether-Lumefantrine in the United Kingdom-Reference-Cited by-同舟云学术

pfk13 -Independent Treatment Failure in Four Imported Cases of Plasmodium falciparum Malaria Treated with Artemether-Lumefantrine in the United Kingdom

Published:2017-03 Issue:3 Volume:61 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Sutherland Colin J.¹²,Lansdell Paul¹,Sanders Mandy³,Muwanguzi Julian²,van Schalkwyk Donelly A.²,Kaur Harparkash²,Nolder Debbie¹,Tucker Julie¹,Bennett Hayley M.³,Otto Thomas D.³,Berriman Matthew³,Patel Trupti A.⁴,Lynn Roderick⁵,Gkrania-Klotsas Effrossyni⁶,Chiodini Peter L.¹⁴

Affiliation:

1. Public Health England Malaria Reference Laboratory, London School of Hygiene & Tropical Medicine, London, United Kingdom

2. Department of Immunology & Infection, Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom

3. Wellcome Trust Sanger Institute, Hinxton, United Kingdom

4. Hospital for Tropical Diseases, London, United Kingdom

5. Haematology Department, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom

6. Infectious Diseases Department, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom

Abstract

ABSTRACT We present case histories of four patients treated with artemether-lumefantrine for falciparum malaria in UK hospitals in 2015 to 2016. Each subsequently presented with recurrent symptoms and Plasmodium falciparum parasitemia within 6 weeks of treatment with no intervening travel to countries where malaria is endemic. Parasite isolates, all of African origin, harbored variants at some candidate resistance loci. No evidence of pfk13 -mediated artemisinin resistance was found. Vigilance for signs of unsatisfactory antimalarial efficacy among imported cases of malaria is recommended.

Funder

Public Health England

Wellcome

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02382-16

Reference15 articles.

1. UK malaria treatment guidelines 2016

2. Spread of Artemisinin Resistance in Plasmodium falciparum Malaria