Varicella-Zoster Virus Proteins in Skin Lesions: Implications for a Novel Role of ORF29p in Chickenpox-Reference-Cited by-同舟云学术

Varicella-Zoster Virus Proteins in Skin Lesions: Implications for a Novel Role of ORF29p in Chickenpox

Published:2000-02-15 Issue:4 Volume:74 Page:2005-2010
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Annunziato Paula W.¹,Lungu Octavian²,Panagiotidis Christos²,Zhang Jing H.¹,Silvers David N.³,Gershon Anne A.¹,Silverstein Saul J.²

Affiliation:

1. Departments of Pediatrics,1

2. Microbiology,2 and

3. Dermatology and Pathology,3 College of Physicians and Surgeons, Columbia University, New York, New York

Abstract

ABSTRACT Skin biopsy samples from varicella-zoster virus (VZV)-infected patients examined by immunohistochemistry demonstrated VZV replication in nonepithelial cell types. ORF29p, a nonstructural nuclear protein, was found in nerves of two of six patients with chickenpox. In tissue culture, ORF29p was secreted by VZV-infected fibroblasts. Extracellular ORF29p can be taken up through endocytosis by human neurons, implying a novel role for this protein in pathogenesis.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.74.4.2005-2010.2000

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