Human Cytomegalovirus Alters Host Cell Mitochondrial Function during Acute Infection

Author:

Combs Joseph A.1,Norton Elizabeth B.1,Saifudeen Zubaida R.2,Bentrup Kerstin Honer Zu1,Katakam Prasad V.3,Morris Cindy A.1,Myers Leann4,Kaur Amitinder5,Sullivan Deborah E.1,Zwezdaryk Kevin J.1

Affiliation:

1. Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, USA

2. Department of Pediatrics, Section of Nephrology, Tulane University School of Medicine, New Orleans, Louisiana, USA

3. Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana, USA

4. Department of Biostatistics and Data Science, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA

5. Tulane National Primate Research Center, Covington, Louisiana, USA

Abstract

Human cytomegalovirus (HCMV) is a herpesvirus present in up to 85% of some populations. Like all herpesviruses, HCMV infection is for life. No vaccine is currently available, neutralizing antibody therapies are ineffective, and current antivirals have limited long-term efficacy due to side effects and potential for viral mutation and resistance. The significance of this research is in understanding how HCMV manipulates the host mitochondria to support bioenergetic and biosynthetic requirements for replication. Despite a large genome, HCMV relies exclusively on host cells for metabolic functions. By understanding the dependency of HCMV on the mitochondria, we could exploit these requirements and develop novel antivirals.

Funder

HHS | NIH | National Institute of General Medical Sciences

HHS | NIH | National Institute of Neurological Disorders and Stroke

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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