ROS Induced by Aphrocallistes vastus Lectin Enhance Oncolytic Vaccinia Virus Replication and Induce Apoptosis in Hepatocellular Carcinoma Cells

Author:

Zhang Yanan1,Zhu Ying1,Jiang Gaohui1,Chen Ke1,Zhang Guohui1ORCID,Chen Kan1,Ye Ting1,Zhou Yanrong1ORCID,Li Gongchu1

Affiliation:

1. College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China

Abstract

Oncolytic virotherapy is expected to provide a new treatment strategy for cancer. Aphrocallistes vastus lectin (AVL) is a Ca2+-dependent lectin receptor containing the conserved domain of C-type lectin and the hydrophobic N-terminal region, which can bind to the bird’s nest glycoprotein and D-galactose. Our previous studies suggested that the oncolytic vaccinia virus (oncoVV) armed with the AVL gene exerted remarkable replication and antitumor effects in vitro and in vivo. In this study, we found that oncoVV-AVL may reprogram the metabolism of hepatocellular carcinoma cells to promote ROS, and elevated ROS subsequently promoted viral replication and induced apoptosis. This study will provide a new theoretical basis for the application of oncoVV-AVL in liver cancer.

Funder

Natural Science Foundation of Zhejiang Province

Zhejiang Provincial Department of Education

State Key Laboratory of Microbial Technology Open Projects Fund

Publisher

MDPI AG

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