Genome-Scale Phylogeny and Evolutionary Analysis of Ross River Virus Reveals Periodic Sweeps of Lineage Dominance in Western Australia, 1977

Genome-Scale Phylogeny and Evolutionary Analysis of Ross River Virus Reveals Periodic Sweeps of Lineage Dominance in Western Australia, 1977–2014

Published:2020-01-06 Issue:2 Volume:94 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Michie Alice¹,Dhanasekaran Vijaykrishna²^ORCID,Lindsay Michael D. A.³,Neville Peter J.³,Nicholson Jay³,Jardine Andrew³,Mackenzie John S.⁴⁵,Smith David W.⁴,Imrie Allison¹⁴

Affiliation:

1. School of Biomedical Sciences, University of Western Australia, Perth, Australia

2. Department of Microbiology, Biomedicine Discovery Institute, Monash University, Melbourne, Australia

3. Environmental Health Hazards, Department of Health, Perth, Western Australia, Australia

4. PathWest Laboratory Medicine Western Australia, Perth, Australia

5. Faculty of Health Sciences, Curtin University, Bentley, Western Australia, Australia

Abstract

Ross River virus (RRV) causes the most common mosquito-borne infection in Australia and causes a significant burden of suffering to infected individuals as well as being a large burden to the Australian economy. The genetic diversity of RRV and its evolutionary history have so far only been studied using partial E2 gene analysis with a limited number of isolates. Robust whole-genome analysis has not yet been conducted. This study generated 94 novel near-whole-genome sequences to investigate the evolutionary history of RRV to better understand its genetic diversity through comprehensive whole-genome phylogeny. A better understanding of RRV genetic diversity will enable better diagnostics, surveillance, and potential future vaccine design.

Funder

Centre of Research Excellence in Emerging Infectious Diseases

Australian Partnership for Preparedness Research on Infectious Disease Emergencies

Department of Health, Government of Western Australia

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01234-19

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