Early Genomic Surveillance and Phylogeographic Analysis of Getah Virus, a Reemerging Arbovirus, in Livestock in China

Author:

Zhao Jin12,Dellicour Simon34ORCID,Yan Ziqing1,Veit Michael5,Gill Mandev S.67,He Wan-Ting124,Zhai Xiaofeng12,Ji Xiang8,Suchard Marc A.91011,Lemey Philippe4,Su Shuo12ORCID

Affiliation:

1. Jiangsu Engineering Laboratory of Animal Immunology, Institute of Immunology, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China

2. Sanya Institute of Nanjing Agricultural University, Sanya, China

3. Spatial Epidemiology Lab (SpELL), Université Libre de Bruxelles, Brussels, Belgium

4. Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory for Clinical and Epidemiological Virology, KU Leuven, Leuven, Belgium

5. Institute for Virology, Center for Infection Medicine, Veterinary Faculty, Free University Berlin, Berlin, Germany

6. Department of Statistics, University of Georgia, Athens, Georgia, USA

7. Institute of Bioinformatics, University of Georgia, Athens, Georgia, USA

8. Department of Mathematics, School of Science & Engineering, Tulane University, New Orleans, Louisiana, USA

9. Department of Biostatistics, Fielding School of Public Health, University of California Los Angeles, Los Angeles, California, USA

10. Department of Biomathematics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA

11. Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA

Abstract

Although livestock is known to be the primary reservoir of Getah virus (GETV) in Asian countries, where identification is largely based on serology, the evolutionary history and spatial epidemiology of GETV in these regions remain largely unknown. Through our sequencing efforts, we provided robust support for lineage delineation of GETV and identified three major lineages that are responsible for the current epidemic in livestock in China.

Funder

National Nature Science Foundation of Outstanding Youth Fund in China, Shuo Su

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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