Decreased In Vitro Artemisinin Sensitivity of Plasmodium falciparum across India

Author:

Chakrabarti Rimi123ORCID,White John12,Babar Prasad H.123,Kumar Shiva12,Mudeppa Devaraja Gouda12,Mascarenhas Anjali123,Pereira Ligia123,Dash Rashmi123,Maki Jennifer N.12,Sharma Ambika123,Gogoi Kabita4,Sarma Devojit K.4,Pal Bhowmick Ipsita4,Manoharan Suresh Kumar123,Gomes Edwin3,Mahanta Jagadish4,Mohapatra Pradyumna Kishore4,Chery Laura12,Rathod Pradipsinh K.12

Affiliation:

1. Department of Chemistry, University of Washington, Seattle, Washington, USA

2. Department of Global Health, University of Washington, Seattle, Washington, USA

3. Department of Medicine, Goa Medical College and Hospital, Bambolim, Goa, India

4. Regional Medical Research Center—Northeast Region (RMRC-NE), Dibrugarh, Assam, India

Abstract

Artemisinin-based combination therapy (ACT) has been used to treat uncomplicated Plasmodium falciparum infections in India since 2004. Since 2008, a decrease in artemisinin effectiveness has been seen throughout the Greater Mekong Subregion. The geographic proximity and ecological similarities of northeastern India to Southeast Asia may differentially affect the long-term management and sustainability of ACT in India.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference55 articles.

1. WHO. 2018. Status report on artemisinin resistance and ACT efficacy. WHO, Geneva, Switzerland.

2. Ministry of Home Affairs Government of India. 2018. International land border. https://mha.gov.in/sites/default/files/BMIntro-1011.pdf.

3. Ministry of Home Affairs Government of India. 2017. Management of Indo-China border. https://mha.gov.in/sites/default/files/INDO%20CHINA_05052017.pdf.

4. Evidence of Artemisinin-Resistant Malaria in Western Cambodia

5. Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate study

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