Azole-Resistant Alleles of <i>ERG11</i> in Candida glabrata Trigger Activation of the Pdr1 and Upc2A Transcription Factors-Reference-Cited by-同舟云学术

Azole-Resistant Alleles of ERG11 in Candida glabrata Trigger Activation of the Pdr1 and Upc2A Transcription Factors

Published:2022-03-15 Issue:3 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Vu Bao Gia¹,Moye-Rowley W. Scott¹^ORCID

Affiliation:

1. Department of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA

Abstract

Azoles, the most commonly used antifungal drugs, specifically inhibit the fungal lanosterol α-14 demethylase enzyme, which is referred to as Erg11. Inhibition of Erg11 ultimately leads to a reduction in ergosterol production, an essential fungal membrane sterol.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.02098-21

Reference45 articles.

1. The Multifunctional Fungal Ergosterol

2. Ergosterol Turnover in Yeast: An Interplay between Biosynthesis and Transport

3. The Fungal CYP51s: Their Functions, Structures, Related Drug Resistance, and Inhibitors