The NaHCO 3 -Responsive Phenotype in Methicillin-Resistant Staphylococcus aureus (MRSA) Is Influenced by mecA Genotype

Author:

Ersoy Selvi C.1ORCID,Manna Adhar C.2ORCID,Proctor Richard A.3,Chambers Henry F.4,Harrison Ewan M.567,Bayer Arnold S.18,Cheung Ambrose2

Affiliation:

1. The Lundquist Institute, Torrance, California, USA

2. Department of Microbiology & Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA

3. University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA

4. UCSF School of Medicine, San Francisco, California, USA

5. Wellcome Sanger Institute, Hinxton, United Kingdom

6. Department of Medicine, University of Cambridge, Cambridge, United Kingdom

7. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

8. The Geffen School of Medicine, University of California, Los Angeles, California, USA

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) strains are a leading cause of many invasive clinical syndromes, and pose treatment difficulties due to their in vitro resistance to most β-lactams on standard laboratory testing. A novel phenotype frequently identified in MRSA strains, termed ‘NaHCO 3 -responsiveness’, is a property whereby strains are susceptible in vitro to many β-lactams in the presence of NaHCO 3 .

Funder

HHS | National Institutes of Health

UK Research and Innovation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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