Role of a Stem-Loop Structure in Helicobacter pylori cagA Transcript Stability-Reference-Cited by-同舟云学术

Role of a Stem-Loop Structure in Helicobacter pylori cagA Transcript Stability

Published:2019-02 Issue:2 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Loh John T.¹,Lin Aung Soe²,Beckett Amber C.²,McClain Mark S.¹,Cover Timothy L.¹²³^ORCID

Affiliation:

1. Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

2. Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

3. Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee, USA

Abstract

Helicobacter pylori CagA is a secreted effector protein that contributes to gastric carcinogenesis. Previous studies showed that there is variation among H. pylori strains in the steady-state levels of CagA and that a strain-specific motif downstream of the cagA transcriptional start site (the +59 motif) is associated with both high levels of CagA and premalignant gastric histology.

Funder

HHS | National Institutes of Health

U.S. Department of Veterans Affairs

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00692-18

Reference48 articles.

1. Coadaptation of Helicobacter pylori and humans: ancient history, modern implications

2. Helicobacter pylori in Health and Disease