Positive Selection of Mutations in the Helicobacter pylori <i>katA</i> 5′ Untranslated Region in a Mongolian Gerbil Model of Gastric Disease-Reference-Cited by-同舟云学术

Positive Selection of Mutations in the Helicobacter pylori katA 5′ Untranslated Region in a Mongolian Gerbil Model of Gastric Disease

Published:2022-07-21 Issue:7 Volume:90 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Loh John T.¹,Shuman Jennifer H. B.²^ORCID,Lin Aung Soe²,Favret Natalie²,Piazuelo M. Blanca¹,Mallal Simon¹³,Chopra Abha³,McClain Mark S.¹⁴^ORCID,Cover Timothy L.¹²⁴⁵^ORCID

Affiliation:

1. Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

2. Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

3. Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Australia

4. Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, Tennesse, USA

5. Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee, USA

Abstract

To evaluate potential effects of gastric inflammation on Helicobacter pylori diversification and evolution within the stomach, we experimentally infected Mongolian gerbils with an H. pylori strain in which Cag type IV secretion system (T4SS) activity is controlled by a TetR/ tetO system. Gerbils infected with H. pylori under conditions in which Cag T4SS activity was derepressed had significantly higher levels of gastric inflammation than gerbils infected under conditions with repressed Cag T4SS activity.

Funder

HHS | National Institutes of Health

U.S. Department of Veterans Affairs

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00004-22

Reference73 articles.

1. The Spectrum of Helicobacter-Mediated Diseases

2. Helicobacter pylori in Health and Disease

3. Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis

4. Identification and molecular analysis of superoxide dismutase isoforms inHelicobacter pylori

5. Superoxide Dismutase-Deficient Mutants of Helicobacter pylori Are Hypersensitive to Oxidative Stress and Defective in Host Colonization

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Reactive oxygen species and gastric carcinogenesis: The complex interaction between Helicobacter pylori and host;Helicobacter;2023-10-05

2. Role of the CagY antenna projection in Helicobacter pylori Cag type IV secretion system activity;Infection and Immunity;2023-09-14

3. A Positively Selected fur -R88H Mutation Enhances Helicobacter pylori Fitness in a High-Salt Environment and Alters Fur-Dependent Regulation of Gene Expression;Infection and Immunity;2023-02-16