Cryo-EM Structure and Functional Studies of EBNA1 Binding to the Family of Repeats and Dyad Symmetry Elements of Epstein-Barr Virus <i>oriP</i>-Reference-Cited by-同舟云学术

Cryo-EM Structure and Functional Studies of EBNA1 Binding to the Family of Repeats and Dyad Symmetry Elements of Epstein-Barr Virus oriP

Published:2022-09-14 Issue:17 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Mei Yang¹,Messick Troy E.¹,Dheekollu Jayaraju¹,Kim Hee Jong²³,Molugu Sudheer²,Muñoz Leonardo Josué Castro¹,Moiskeenkova-Bell Vera²,Murakami Kenji²,Lieberman Paul M.¹^ORCID

Affiliation:

1. The Wistar Institute, Philadelphia, Pennsylvania, USA

2. Department of Biochemistry and Biophysics, the Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

3. Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

Abstract

EBV latent infection is causally linked to diverse cancers and autoimmune disorders. EBNA1 is the viral-encoded DNA binding protein required for episomal maintenance during latent infection and is consistently expressed in all EBV tumors.

Funder

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute of General Medical Sciences

National Science Foundation

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00949-22

Reference61 articles.

1. Epstein–Barr virus: 40 years on