Affiliation:
1. Divisions of Virology
2. Mathematical Biology, National Institute for Medical Research, London, United Kingdom
Abstract
ABSTRACT
The specificity determinants for susceptibility to resistance by the
Fv1
n and b alleles map to amino acid 110 of the murine leukemia virus CA protein. To study the interaction between
Fv1
and CA, we examined changes in CA resulting in the loss of susceptibility to
Fv1
resistance in naturally occurring NB- and NR-tropic viruses. A variety of amino acid changes affecting Fv1 tropism were identified, at CA positions 82, 92 to 95, 105, 114, and 117, and they all were mapped to the apparent exterior of virion-associated CA. These amino acids may form a binding surface for Fv1.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
Cited by
55 articles.
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