Affiliation:
1. Department of Medical Education, Providence Portland Medical Center, and Department of Medicine, Oregon Health and Science University, Portland, Oregon
Abstract
ABSTRACT
Procalcitonin (PCT) is synthesized by a large number of tissues and organs in response to invasion by pathogenic bacteria, fungi, and some parasites. Current PCT assays are rapid, specific, and of sufficient sensitivity to detect increases in PCT serum levels within 4 to 6 h of initiation of infection. Clinically, PCT levels may help in decisions regarding the need for empirical antibiotic therapy, “source control” of infection, and duration of antibiotic therapy. The addition of PCT levels to bacterial culture and viral detection results can assist with the separation of colonization and invasion by pathogenic bacteria.
Publisher
American Society for Microbiology
Reference42 articles.
1. Ammori, B. J., K. L. Becker, P. Kite, R. H. Snider, E. S. Nylen, J. C. White, G. R. Barclay, M. Larvin, and M. J. McMahon. 2003. Calcitonin precursors: early markers of gut barrier dysfunction in patients with acute pancreatitis. Pancreas 27 : 239-243.
2. Assicot, M., D. Gendrel, H. Carsin, J. Raymond, J. Guilband, and C. Bohuon. 1993. High serum procalcitonin concentrations in patients with sepsis and infection. Lancet 341 : 515-538.
3. Becker, K. L., E. S. Nylen, J. C. White, B. Muller, and R. H. Snider. 2004. Procalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis: a journey from calcitonin back to its precursors. J. Clin. Endocrinol. Metab. 89 : 1512-1525.
4. Becker, K. L., R. Snider, and E. S. Nylen. 2008. Procalcitonin assay in systemic inflammation, infection, and sepsis: clinical utility and limitations. Crit. Care Med. 36 : 941-952.
5. Charles, P. E., C. Tinel, S. Barbar, S. Aho, S. Prin, J. M. Doise, N. O. Olsson, B. Blettery, and J. P. Quenot. 2009. Procalcitonin kinetics within the first days of sepsis: relationship with the appropriateness of antibiotic therapy and the outcome. Crit. Care 19 : R38.
Cited by
117 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献