A Mutant of Mycobacterium smegmatis Defective in Dipeptide Transport

Author:

Bhatt Achal1,Green Renee1,Coles Roswell1,Condon Michael2,Connell Nancy D.13

Affiliation:

1. Department of Microbiology and Molecular Genetics1 and

2. Department of Medicine, and Department of Surgery,3 UMDNJ/New Jersey Medical School, Newark, New Jersey 07103

3. National Tuberculosis Center,2

Abstract

ABSTRACT A mutant of Mycobacterium smegmatis unable to use the dipeptide carnosine (β-alanyl- l -histidine) as a sole carbon or nitrogen source was isolated. Carnosinase activity and the ability to grow on β-Ala and/or l -His were similar in the mutant and the wild type. However, the mutant showed significant impairment in the uptake of carnosine. This study is the first description of a peptide utilization mutant of a mycobacterium.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference19 articles.

1. Mycobacterium: isolation, maintenance, transformation and mutant selection;Connell N. D.;Methods Cell Biol.,1994

2. Beta-alanine synthesis in Escherichia coli

3. 2-Ketoglutarate and the regulation of aconitase and histidase formation in Bacillus subtilis

4. Genetic basis of histidine degradation in Bacillus subtilis;Kimhi Y.;J. Biol. Chem.,1970

5. Salmonella typhimurium peptidase active on carnosine;Kirsch M.;J. Bacteriol.,1978

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