Transport of Intact Porphyrin by HpuAB, the Hemoglobin-Haptoglobin Utilization System of Neisseria meningitidis-Reference-Cited by-同舟云学术

Transport of Intact Porphyrin by HpuAB, the Hemoglobin-Haptoglobin Utilization System of Neisseria meningitidis

Published:1998-11-15 Issue:22 Volume:180 Page:6043-6047
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Lewis L. A.¹,Sung M.-H.¹,Gipson M.¹,Hartman K.¹,Dyer D. W.¹

Affiliation:

1. Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73103

Abstract

ABSTRACT The meningococcal hemA gene was cloned and used to construct a porphyrin biosynthesis mutant. An analysis of the hemA mutant indicated that meningococci can transport intact porphyrin from heme (Hm), hemoglobin (Hb), and Hb-haptoglobin (Hp). By constructing a HemA − HpuAB − double mutant, we demonstrated that HpuAB is required for the transport of porphyrin from Hb and Hb-Hp.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.180.22.6043-6047.1998

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