Affiliation:
1. Division of Infectious Diseases, Department of Medicine, The Ohio State University College of Medicine, Columbus, Ohio 43210
Abstract
The minimal inhibitory concentrations of clindamycin and gentamicin alone and in combinations were determined by a microdilution method for 163 aerobic, facultative, and anaerobic clinical isolates. All 77 strains of
Staphylococcus aureus, Diplococcus pneumoniae, Streptococcus pyogenes
, and anaerobic bacteria (except for three strains of
Clostridium
) were inhibited by 1.6 μg or less of clindamycin per ml. Gentamicin did not interfere with the activity of clindamycin within the range of concentrations tested (0.1 to 100 μg/ml); for some strains combinations were synergistic. Sixty-two (94%) of 66 strains of
Enterobacteriaceae
and
Pseudomonas aeruginosa
were inhibited by 6.2 μg or less of gentamicin per ml. Combinations of clindamycin and gentamicin were indifferent for 29 strains and synergistic for 33 strains. All 20 strains of enterococcus, three strains of
Clostridium
, three strains of
Escherichia coli
, and one strain of
Proteus rettgeri
were resistant to both clindamycin (minimal inhibitory concentration greater than 3.1 μg/ml) and gentamicin (minimal inhibitory concentration greater than 6.2 μg/ml). Combinations of clindamycin and gentamicin were indifferent for 16 and synergistic for 11 of the resistant strains. Except for clindamycin-sensitive isolates, synergy was usually observed only at concentrations of one or both drugs which are not readily obtainable in vivo. Antagonism was never observed.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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