Antiviral Activity of 2-Acetylpyridine Thiosemicarbazones Against Herpes Simplex Virus

Author:

Shipman Charles1,Smith Sandra H.1,Drach John C.1,Klayman Daniel L.2

Affiliation:

1. Dental Research Institute, School of Dentistry, The University of Michigan, Ann Arbor, Michigan 48109,

2. Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, D.C. 20012

Abstract

2-Acetylpyridine thiosemicarbazone derivatives inhibited the replication of herpes simplex virus types 1 and 2 to a greater extent than cellular deoxyribonucleic acid or protein synthesis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference20 articles.

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2. The antiviral and synergic actions of isatin thiosemicarbazone and certain phenoxypyrimidines in vaccinia infection in mice;Bauer D. J.;Br. J. Exp. Pathol.,1955

3. Clinical experience with the antiviral drug Marboran (1-methylisatin 3-thiosemicarbazone);Bauer D. J.;Ann. N. Y. Acad. Sci.,1965

4. Bauer D. J. L St. Vincent C. H. Kempe and A. W. Downie. 1963. Prophylactic treatment of smallpox con- tacts with N-methylisatin B-thiosemicarbazone. Lancet ii:494-496.

5. Prophylaxis of smallpox with methisazone;Bauer D. J.;Am. J. Epidemiol.,1969

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