Minocycline Alone and in Combination with Polymyxin B, Meropenem, and Sulbactam against Carbapenem-Susceptible and -Resistant Acinetobacter baumannii in an In Vitro Pharmacodynamic Model

Author:

Beganovic Maya12,Daffinee Kathryn E.1,Luther Megan K.123,LaPlante Kerry L.12345ORCID

Affiliation:

1. Infectious Diseases Research Program, Providence Veterans Affairs Medical Center, Providence, Rhode Island, USA

2. College of Pharmacy, University of Rhode Island, Kingston, Rhode Island, USA

3. Center of Innovation in Long-Term Support Services, Providence Veterans Affairs Medical Center, Providence, Rhode Island, USA

4. Division of Infectious Diseases, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA

5. School of Public Health, Brown University, Providence, Rhode Island, USA

Abstract

Acinetobacter baumannii is recognized as an urgent public health threat by the Centers for Disease Control and Prevention (CDC). Current treatment options are scarce, particularly against carbapenem-resistant Acinetobacter baumannii (CRAB).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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