In VitroSusceptibility of Mycobacterium tuberculosis to Trimethoprim and Sulfonamides in France

Abstract

ABSTRACTFive type strains and 55Mycobacterium tuberculosiscomplex clinical isolates were found resistant to trimethoprim with a MIC of >200 mg/liter and susceptible to both sulfadiazine and cotrimoxazole with a MIC90of 10 mg/liter. TwoM. canettiiisolates uniquely yielded silent mutations C156→ T and G238→ C in thefolP1gene. Combined with scarce published data, these data indicate that sulfamides could be considered alternative antituberculous antibiotics.