Inhibition of Porphyromonas gingivalis Biofilm by Oxantel-Reference-Cited by-同舟云学术

Inhibition of Porphyromonas gingivalis Biofilm by Oxantel

Published:2010-03 Issue:3 Volume:54 Page:1311-1314
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Dashper Stuart¹,Ang Ching-Seng¹,Liu Sze Wei¹,Paolini Rita¹,Veith Paul¹,Reynolds Eric¹

Affiliation:

1. Cooperative Research Centre for Oral Health Science, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Melbourne, Australia

Abstract

ABSTRACT Porphyromonas gingivalis is a major pathogen of chronic periodontitis and exists in a biofilm on the surface of the tooth root. Oxantel, a cholinergic anthelmintic and fumarate reductase inhibitor, significantly inhibited biofilm formation by P. gingivalis and disrupted established biofilms at concentrations below its MIC against planktonic cells. Oxantel was more effective against P. gingivalis in biofilm than metronidazole, a commonly used antibiotic for periodontitis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00946-09

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