Conformation of HIV-1 Envelope Governs Rhesus CD4 Usage and Simian-Human Immunodeficiency Virus Replication-Reference-Cited by-同舟云学术

Conformation of HIV-1 Envelope Governs Rhesus CD4 Usage and Simian-Human Immunodeficiency Virus Replication

Published:2022-02-22 Issue:1 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Vilmen Geraldine¹²,Smith Anna C.¹²,Benet Hector Cervera³,Shukla Rajni Kant¹²,Larue Ross C.⁴,Herschhorn Alon³,Sharma Amit¹²^ORCID

Affiliation:

1. Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA

2. Department of Microbial Infection & Immunity, The Ohio State University, Columbus, Ohio, USA

3. Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA

4. Department of Cancer Biology and Genetics, The Ohio State University, Columbus, Ohio, USA

Abstract

Rhesus macaques are a critical animal model for preclinical testing of HIV-1 vaccine and prevention approaches. However, HIV-1 does not replicate in rhesus macaques, and thus, chimeric simian-human immunodeficiency viruses (SHIVs), which encode HIV-1 envelope glycoproteins (Envs), are used as surrogate challenge viruses to infect rhesus macaques for modeling HIV-1 infection.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Ohio State University

HHS | NIH | National Institute on Drug Abuse

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.02752-21

Reference45 articles.

1. Animal models for HIV/AIDS research