CCR2 Signaling Restricts SARS-CoV-2 Infection

Author:

Vanderheiden Abigail123,Thomas Jeronay45,Soung Allison L.6,Davis-Gardner Meredith E.123,Floyd Katharine123,Jin Fengzhi234,Cowan David A.237,Pellegrini Kathryn237,Shi Pei-Yong8,Grakoui Arash234,Klein Robyn S.6910,Bosinger Steven E.237,Kohlmeier Jacob E.45,Menachery Vineet D.11ORCID,Suthar Mehul S.1235ORCID

Affiliation:

1. Center for Childhood Infections and Vaccines of Children’s Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA

2. Emory Vaccine Center, Emory University, Atlanta, Georgia, USA

3. Yerkes National Primate Research Center, Atlanta, Georgia, USA

4. Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA

5. Emory-UGA Center of Excellence of Influenza Research and Surveillance (CEIRS), Atlanta, Georgia, USA

6. Center for Neuroimmunology and Neuroinfectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA

7. Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA

8. Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, Texas, USA

9. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA

10. Department of Neurosciences, Washington University School of Medicine, St. Louis, Missouri, USA

11. Department of Microbiology and Immunology, Institute for Human Infection and Immunity, World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, Texas, USA

Abstract

SARS-CoV-2 has caused a historic pandemic of respiratory disease (COVID-19), and current evidence suggests that severe disease is associated with dysregulated immunity within the respiratory tract. However, the innate immune mechanisms that mediate protection during COVID-19 are not well defined.

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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