Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans-Reference-Cited by-同舟云学术

Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

Published:2020-09-04 Issue:6508 Volume:369 Page:1210-1220
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Arunachalam Prabhu S.¹^ORCID,Wimmers Florian¹^ORCID,Mok Chris Ka Pun²^ORCID,Perera Ranawaka A. P. M.³^ORCID,Scott Madeleine¹⁴^ORCID,Hagan Thomas¹^ORCID,Sigal Natalia¹^ORCID,Feng Yupeng¹^ORCID,Bristow Laurel⁵^ORCID,Tak-Yin Tsang Owen⁶,Wagh Dhananjay⁷^ORCID,Coller John⁷,Pellegrini Kathryn L.⁸^ORCID,Kazmin Dmitri¹,Alaaeddine Ghina⁵^ORCID,Leung Wai Shing⁶^ORCID,Chan Jacky Man Chun⁶,Chik Thomas Shiu Hong⁶^ORCID,Choi Chris Yau Chung⁶^ORCID,Huerta Christopher⁵,Paine McCullough Michele⁵,Lv Huibin²,Anderson Evan⁹^ORCID,Edupuganti Srilatha⁵^ORCID,Upadhyay Amit A.⁸^ORCID,Bosinger Steve E.⁸¹⁰^ORCID,Maecker Holden Terry¹^ORCID,Khatri Purvesh¹⁴^ORCID,Rouphael Nadine⁵,Peiris Malik²³^ORCID,Pulendran Bali¹¹¹¹²^ORCID

Affiliation:

1. Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA.

2. HKU-Pasteur Research Pole, School of Public Health, HKU Li Ka Shing Faculty of Medicine, The University of Hong Kong (HKU), Hong Kong.

3. Centre of Influenza Research, School of Public Health, HKU Li Ka Shing Faculty of Medicine, HKU, Hong Kong.

4. Center for Biomedical Informatics, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

5. Hope Clinic of the Emory Vaccine Center, Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Decatur, GA 30030, USA.

6. Infectious Diseases Centre, Princess Margaret Hospital, Hospital Authority of Hong Kong, Hong Kong.

7. Stanford Functional Genomics Facility, Stanford University School of Medicine, Stanford, CA 94305, USA.

8. Emory Vaccine Center, Yerkes National Primate Research Center, Atlanta, GA 30329, USA.

9. Department of Pediatrics, Division of Infectious Disease, Emory University School of Medicine, Atlanta, GA 30322, USA.

10. Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30329, USA.

11. Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

12. Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Abstract

Immune profiling of COVID-19 patients Coronavirus disease 2019 (COVID-19) has affected millions of people globally, yet how the human immune system responds to and influences COVID-19 severity remains unclear. Mathew et al. present a comprehensive atlas of immune modulation associated with COVID-19. They performed high-dimensional flow cytometry of hospitalized COVID-19 patients and found three prominent and distinct immunotypes that are related to disease severity and clinical parameters. Arunachalam et al. report a systems biology approach to assess the immune system of COVID-19 patients with mild-to-severe disease. These studies provide a compendium of immune cell information and roadmaps for potential therapeutic interventions. Science , this issue p. eabc8511 , p. 1210

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference43 articles.

1. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China

2. Preliminary Estimates of the Prevalence of Selected Underlying Health Conditions Among Patients with Coronavirus Disease 2019 — United States, February 12–March 28, 2020

3. Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology

4. Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

5. Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

Cited by 908 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Type I and type III interferons: From basic biology and genetics to clinical development for COVID-19 and beyond;Seminars in Immunology;2024-03

2. Single-cell atlas of the liver myeloid compartment before and after cure of chronic viral hepatitis;Journal of Hepatology;2024-02

3. scDisInFact: disentangled learning for integration and prediction of multi-batch multi-condition single-cell RNA-sequencing data;Nature Communications;2024-01-30

4. Antibody and transcription landscape in peripheral blood mononuclear cells of elderly adults over 70 years of age with third dose of COVID-19 BBIBP-CorV and ZF2001 booster vaccine;Immunity & Ageing;2024-01-27

5. Early immune factors associated with the development of post-acute sequelae of SARS-CoV-2 infection in hospitalized and non-hospitalized individuals;Frontiers in Immunology;2024-01-22