Affiliation:
1. Centre for Infection and Biomaterials Research, Hospital for Sick Children, and Department of Surgery, University of Toronto, Toronto, Canada
Abstract
ABSTRACT
Under static growth conditions, hyperpiliated, nontwitching
pilT
and
pilU
mutants of
Pseudomonas aeruginosa
formed dense biofilms, showing that adhesion, not twitching motility, is necessary for biofilm initiation. Under flow conditions, the
pilT
mutant formed mushroom-like structures larger than those of the wild type but the
pilU
mutant was defective in biofilm formation. Therefore, twitching motility affects the development of biofilm structure, possibly through modulation of detachment.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
147 articles.
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