In Vitro Susceptibility of Plasmodium falciparum Isolates from the China-Myanmar Border Area to Piperaquine and Association with Candidate Markers-Reference-Cited by-同舟云学术

In Vitro Susceptibility of Plasmodium falciparum Isolates from the China-Myanmar Border Area to Piperaquine and Association with Candidate Markers

Published:2021-04-19 Issue:5 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Si Yu¹,Zeng Weilin¹,Li Na¹,Wang Chengqi²,Siddiqui Faiza²,Zhang Jie¹,Pi Liang¹,He Xi¹,Zhao Luyi¹,Wang Siqi¹,Zhao Hui¹,Li Xinxin¹,Yang Qi¹,Miao Jun²,Yang Zhaoqing¹,Cui Liwang²^ORCID

Affiliation:

1. Department of Pathogen Biology and Immunology, Kunming Medical University, Kunming, Yunnan Province, China

2. Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA

Abstract

Plasmodium falciparum from the Greater Mekong subregion has evolved resistance to the artemisinin-based combination therapy dihydroartemisinin and the partner drug piperaquine. To monitor the potential westward spread or independent evolution of piperaquine resistance, we evaluated the in vitro susceptibility of 120 P. falciparum isolates collected at the China-Myanmar border during 2007 to 2016.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02305-20

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