Affiliation:
1. Department of Genetics, Institut National Agronomique, Paris, France
Abstract
Observation of the growth of some adenineless mutants of
Schizosaccharomyces pombe
on six substituted purine analogs leads to the hypothesis that an enzyme is present which catalyzes the conversion of these analogs into hypoxanthine. The enzyme adenase (adenine aminohydrolase, EC 3.5.4.2) has been found to be active in cell-free extracts of
S. pombe
. Results are reported which are in agreement with the hypothesis that this enzyme is responsible for the in vivo utilization of 6-chloropurine. This evidence comes mainly from a study of adenine aminohydrolase in two mutants selected for partial inability to grow on 6-chloropurine.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Reference9 articles.
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5. Purine catabolism in Drosophila melanogaster I. Reactions leading to xanthine dehydrogenase;Hodge L. D.;Biochim. Biophys. Acta,1967
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