Uncovering Roles of Streptococcus gordonii SrtA-Processed Proteins in the Biofilm Lifestyle

Author:

Nairn Brittany L.1,Lee Grace T.2,Chumber Ashwani K.1,Steck Patrick R.2,Mire Mahmoud O.2,Lima Bruno P.2ORCID,Herzberg Mark C.2ORCID

Affiliation:

1. Department of Biological Sciences, Bethel University, St. Paul, Minnesota, USA

2. Department of Biological and Diagnostic Sciences, University of Minnesota, Minneapolis, Minnesota, USA

Abstract

S. gordonii interactions with its environment depend on the complement of cell wall proteins. A subset of these cell wall proteins requires processing by the enzyme sortase A (SrtA). The identification of SrtA-processed proteins and their functional characterization will help the community to better understand how S. gordonii engages with its surroundings, including other microbes, integrates into the plaque community, adheres to the tooth surface, and hematogenously disseminates to cause blood-borne infections. This study identified 26 putative SrtA-processed proteins through creation of a markerless deletion mutant library. The library was subject to functional screens that were chosen to better understand key aspects of S. gordonii physiology and pathogenesis.

Funder

HHS | NIH | National Institute of Dental and Craniofacial Research

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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