Partial Excision of the Chromosomal Cassette Containing the Methicillin Resistance Determinant Results in Methicillin-Susceptible Staphylococcus aureus-Reference-Cited by-同舟云学术

Partial Excision of the Chromosomal Cassette Containing the Methicillin Resistance Determinant Results in Methicillin-Susceptible Staphylococcus aureus

Published:2005-08 Issue:8 Volume:43 Page:4191-4193
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Donnio Pierre-Yves¹²,Oliveira Duarte C.³,Faria Nuno A.³,Wilhelm Nathalie⁴,Le Coustumier Alain⁴,de Lencastre Herminia³⁵

Affiliation:

1. Laboratoire de Bactériologie-Virologie, Centre Hospitalier Universitaire, 35033 Rennes, France

2. UPRES-1254 Microbiologie, Université Rennes I, 35043 Rennes, France

3. Instituto de Tecnología Química e Biológica, Universidade Nova de Lisboa, 2780-156 Oeiras, Portugal

4. Laboratoire de Biologie, Centre Hospitalier, 46005 Cahors, France

5. Laboratory of Microbiology, The Rockefeller University, New York, New York 10021

Abstract

ABSTRACT We report a detailed characterization of methicillin-susceptible Staphylococcus aureus isolates from five French hospitals negative for both the mecA and the ccrAB loci but positive for the IS 431 ::pUB110::IS 431 :: dcs structure, present in some Staphylococcus cassette chromosome mec (SCC mec ) types. The presence of SCC mec -associated elements suggests that this unusual resistant phenotype is due to a partial excision of SCC mec from epidemic methicillin-resistant S. aureus . The hypothesis of a genetic relatedness is strengthened by common sequence and spa types and similar susceptibility patterns.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.43.8.4191-4193.2005

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