Vibrio cholerae TolC Is Required for Expression of the ToxR Regulon-Reference-Cited by-同舟云学术

Vibrio cholerae TolC Is Required for Expression of the ToxR Regulon

Published:2021-09-16 Issue:10 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Weng Yuding¹,Fields Edith G.¹,Bina Thomas F.¹,Budnick James A.²,Kunkle Dillon E.¹,Bina X. Renee¹,Bina James E.¹^ORCID

Affiliation:

1. University of Pittsburgh School of Medicine, Department of Microbiology and Molecular Genetics, Pittsburgh, Pennsylvania, USA

2. University of Pittsburgh School of Medicine, Division of Infectious Diseases, Department of Medicine, Pittsburgh, Pennsylvania, USA

Abstract

Vibrio cholerae is a Gram-negative bacterium that causes the enteric disease cholera. V. cholerae colonization of the human intestine is dependent on the expression of both virulence genes and environmental adaptation genes involved in antimicrobial resistance. The expression of virulence genes, including the genes encoding the main virulence factors cholera toxin (CT) and the toxin-coregulated pilus (TCP), are coordinately regulated by the ToxR regulon.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00242-21

Reference62 articles.

1. Cholera

2. Pathogenic Vibrios in the Natural Aquatic Environment