Examining the Distribution and Impact of Single-Nucleotide Polymorphisms in the Capsular Locus of Streptococcus pneumoniae Serotype 19A-Reference-Cited by-同舟云学术

Examining the Distribution and Impact of Single-Nucleotide Polymorphisms in the Capsular Locus of Streptococcus pneumoniae Serotype 19A

Published:2021-10-15 Issue:11 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Arends D. W.¹^ORCID,Miellet W. R.²,Langereis J. D.¹^ORCID,Ederveen T. H. A.³,van der Gaast–de Jongh C. E.¹,van Scherpenzeel M.⁴⁵,Knol M. J.²,van Sorge N. M.⁶,Lefeber D. J.⁵,Trzciński K.⁷,Sanders E. A. M.²⁷,Dorfmueller H. C.⁸,Bootsma H. J.¹²,de Jonge M. I.¹^ORCID

Affiliation:

1. Laboratory of Medical Immunology, Radboud Center for Infectious Diseases, Radboud Institute for Molecular Sciences, Radboud University Medical Center, Nijmegen, The Netherlands

2. National Institute for Public Health and the Environment, Bilthoven, The Netherlands

3. Center for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands

4. GlycoMScan, Oss, The Netherlands

5. Translational Metabolic Laboratory, Department of Neurology, Radboud University Medical Center, Nijmegen, The Netherlands

6. Department of Medical Microbiology and Infection Prevention, Netherlands Reference Laboratory for Bacterial Meningitis, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands

7. Department of Paediatric Immunology and Infectious Diseases, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands

8. Division of Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee, United Kingdom

Abstract

Streptococcus pneumoniae serotype 19A prevalence has increased after the implementation of the PCV7 and PCV10 vaccines. In this study, we have provided, with high accuracy, the genetic diversity of the 19A serotype in a cohort of Dutch invasive pneumococcal disease patients and asymptomatic carriers obtained in the period from 2004 to 2016.

Funder

Royal Society

VWS | Rijksinstituut voor Volksgezondheid en Milieu

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00246-21

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2. Genetic Alteration of Capsule Type but Not PspA Type Affects Accessibility of Surface-Bound Complement and Surface Antigens of Streptococcus pneumoniae