Pan-Genome-Wide Association Study of Serotype 19A Pneumococci Identifies Disease-Associated Genes-Reference-Cited by-同舟云学术

Pan-Genome-Wide Association Study of Serotype 19A Pneumococci Identifies Disease-Associated Genes

Published:2023-08-17 Issue:4 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Li Ting¹,Huang Jiayin¹,Yang Shimin¹,Chen Jianyu¹,Yao Zhenjiang¹^ORCID,Zhong Minghao²,Zhong Xinguang²,Ye Xiaohua¹^ORCID

Affiliation:

1. School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China

2. Department of Prevention and Health Care, The Sixth People’s Hospital of Dongguan City, Guangdong, China

Abstract

It is important to understand the genetic and pathogenic characteristics of S. pneumoniae serotype 19A, which may provide important information for the prevention and treatment of pneumococcal disease. This global large-sample pan-GWAS study has identified a subset of 30 consistently significant disease-associated genes that are involved in mobile genetic elements, antibiotic resistance, virulence, and cellular metabolism.

Funder

MOST | National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.04073-22

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