Pathologic changes during acute Q fever: influence of the route of infection and inoculum size in infected guinea pigs-Reference-Cited by-同舟云学术

Pathologic changes during acute Q fever: influence of the route of infection and inoculum size in infected guinea pigs

Published:1997-06 Issue:6 Volume:65 Page:2443-2447
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

La Scola B¹,Lepidi H¹,Raoult D¹

Affiliation:

1. Unité des Rickettsies, UPRESA 6020, Faculté de Medecine, Université de la Mediterrannée, Marseille, France.

Abstract

As assessed by both standard histological staining and immunochemistry, intraperitoneal inoculation of C. burnetii in guinea pigs led to pathologic changes mainly in the liver, whereas intranasal inoculation led to pathologic changes mainly in the lungs. Myocarditis and positive blood cultures were observed only in those animals which received the highest inoculum. We therefore conclude that both the route of infection and the size of the inoculum influence clinical expression in acute Q fever.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.65.6.2443-2447.1997

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