Fitness Cost of Staphylococcal Cassette Chromosome mec in Methicillin-Resistant Staphylococcus aureus by Way of Continuous Culture

Author:

Lee Sui Mae1,Ender Miriam2,Adhikari Rajan12,Smith John M. B.1,Berger-Bächi Brigitte2,Cook Gregory M.1

Affiliation:

1. Department of Microbiology and Immunology, Otago School of Medical Sciences, University of Otago, P.O. Box 56, Dunedin, New Zealand

2. Institute of Medical Microbiology, University of Zürich, Gloriastr. 32, CH8006 Zürich, Switzerland

Abstract

ABSTRACT We examined the effect of introducing type I or IV staphylococcal cassette chromosome mec (SCC mec ) elements on the growth yield of Staphylococcus aureus in glucose-limited continuous culture. Type I showed increased glucose consumption and ATP demand per gram of cells synthesized and decreased cell yield compared to those of the parent strain. In contrast, type IV SCC mec elements had no adverse energetic effect.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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