Genetic Aspects of Mycobacterium Tuberculosis Resistance to New Anti-Tuberculosis Drugs

Author:

Kukurika A. V.1,Veselova E. I.1,Peregudova A. B.1

Affiliation:

1. National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health

Abstract

We analyzed 57 publications devoted to study of genetic mechanisms of formation of drug resistance of Mycobacterium tuberculosis to bedaquiline, delamanid, pretomanid, linezolid, and clofazimine. Identification of genetic factors of MTB drug resistance make the basis to search for new targets in development of anti-tuberculosis drugs and methods for drug susceptibility testing.

Publisher

LLC "Medical Knowledge and Technologies"

Subject

General Medicine

Reference57 articles.

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4. Andries K., Villellas C., Coeck N., Thys K., Gevers T., Vranckx L., Andries K., Villellas C., Coeck N., Thys K., Gevers T., Vranckx L. et al. Acquired resistance of Mycobacterium tuberculosis to bedaquiline. PLoS One, 2014, no. 9, pp. e102135.

5. Battaglia S., Spitaleri A., Cabibbe A. M., Meehan C. J., Utpatel C., Ismail N., Tahseen S., Skrahina A., Alikhanova N., Mostofa Kamal S. M., Barbova A., Niemann S., Groenheit R., Dean A. S., Zignol M., Rigouts L., Cirillo D. M. Characterization of Genomic Variants Associated with Resistance to Bedaquiline and Delamanid in Naive Mycobacterium tuberculosis Clinical Strains // J. Clin. Microbiol. // 2020. - Vol. 58, № 11. - Р. e01304-20.

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