Characterization of Genomic Variants Associated with Resistance to Bedaquiline and Delamanid in Naive Mycobacterium tuberculosis Clinical Strains-Reference-Cited by-同舟云学术

Characterization of Genomic Variants Associated with Resistance to Bedaquiline and Delamanid in Naive Mycobacterium tuberculosis Clinical Strains

Published:2020-10-21 Issue:11 Volume:58 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Battaglia S.¹^ORCID,Spitaleri A.¹²^ORCID,Cabibbe A. M.¹^ORCID,Meehan C. J.³⁴^ORCID,Utpatel C.⁵,Ismail N.⁶^ORCID,Tahseen S.⁷,Skrahina A.⁸,Alikhanova N.⁹,Mostofa Kamal S. M.¹⁰,Barbova A.¹¹,Niemann S.⁵¹²,Groenheit R.¹³,Dean A. S.¹⁴,Zignol M.¹⁴,Rigouts L.⁴¹⁵,Cirillo D. M.¹^ORCID

Affiliation:

1. Emerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy

2. Center for Omics Sciences, IRCCS San Raffaele Scientific Institute, Milan, Italy

3. School of Chemistry and Biosciences, University of Bradford, Bradford, United Kingdom

4. Unit of Mycobacteriology, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium

5. Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany

6. Centre for Tuberculosis, National Institute for Communicable Diseases, National Health Laboratory Services, Johannesburg, South Africa

7. National TB Reference Laboratory, National Tuberculosis Control Program, Islamabad, Pakistan

8. Republic Research and Practical Centre for Pulmonology and Tuberculosis, Minsk, Belarus

9. Scientific Research Institute of Lung Diseases, Ministry of Health, Baku, Azerbaijan

10. National TB Reference Laboratory, National Institute of Diseases of the Chest and Hospital, Dhaka, Bangladesh

11. Central Reference Laboratory on Tuberculosis Microbiological Diagnostics, Ministry of Health, Kiev, Ukraine

12. German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany

13. Unit for Laboratory Surveillance of Bacterial Pathogens, Public Health Agency of Sweden, Solna, Sweden

14. Global TB Programme, World Health Organization, Geneva, Switzerland

15. Department of Biomedical Sciences, Antwerp University, Antwerp, Belgium

Abstract

The role of mutations in genes associated with phenotypic resistance to bedaquiline (BDQ) and delamanid (DLM) in Mycobacterium tuberculosis complex (MTBc) strains is poorly characterized. A clear understanding of the genetic variants’ role is crucial to guide the development of molecular-based drug susceptibility testing (DST). In this work, we analyzed all mutations in candidate genomic regions associated with BDQ- and DLM-resistant phenotypes using a whole-genome sequencing (WGS) data set from a collection of 4,795 MTBc clinical isolates from six countries with a high burden of tuberculosis (TB).

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01304-20

Reference60 articles.

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