Evaluation of Clinical and Economic Efficiency and Impact of Mass Fluorography Screening on Tuberculosis Epidemiological Rates in Four Federal Districts of the Russian Federation with Different Levels of Population Coverage with Mass Fluorography Screening

Author:

Peretsmanas E. O.1ORCID,Orlova-Morozova E. A.1,Esin I. V.1,Kaminsky G. D.1ORCID,Tyulkova T. E.1ORCID,Panova A. E.1,Lovacheva O. V. O. V.1

Affiliation:

1. National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health, Moscow

Abstract

The objective: analysis of clinical cases of tuberculous spondylitis in HIV-infected patients with the detection of HIV RNA in the focus of vertebral bodies destruction.Subjects and Methods. Medical records of 2 HIV-infected patients who underwent surgery for verified tuberculous spondylitis were analyzed. Parts of the vertebral bodies collected during surgery were examined (PCR, microbiological and histological tests), those were parts with destruction and fragments of healthy iliac bone necessary to fill the implant during corporodesis.Results. RNA HIV was detected in the foci of bone destructionas as well as M. tuberculosis DNA. The viral load in the fragments of healthy iliac bone and peripheral blood of these patients was undetectable.

Publisher

LLC "Medical Knowledge and Technologies"

Subject

General Medicine

Reference9 articles.

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4. Lamers S. L., Rose R., Maidji E., Agsalda-Garcia M., Nolan D. J., Fogel G. B., Salemi M., Garcia D. L., Bracci P., Yong W., Commins D., Said J., Khanlou N., Hinkin C. H., Sueiras M. V., Mathisen G., Donovan S., Shiramizu B., Stoddart C. A., McGrath M. S., Singer E. J. HIV DNA is frequently present within pathologic tissues evaluated at Autopsy from Combined Antiretroviral Therapy-Treated Patients with Undetectable Viral Loads. J. Virol., 2016, Sep 29, 90(20), 8968–83. doi: 10.1128/JVI.00674-16. PMID: 27466426; PMCID: PMC5044815.

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