NADPH oxidase inhibitor development for diabetic nephropathy through water tank model

Author:

Lee Hye EunORCID,Shim SeunghwanORCID,Choi YongseokORCID,Bae Yun SooORCID

Abstract

Oxidative stress can cause generation of uncontrolled reactive oxygen species (ROS) and lead to cytotoxic damage to cells and tissues. Recently, it has been shown that transient ROS generation can serve as a secondary messenger in receptor-mediated cell signaling. Although excessive levels of ROS are harmful, moderated levels of ROS are essential for normal physiological function. Therefore, regulating cellular ROS levels should be an important concept for development of novel therapeutics for treating diseases. The overexpression and hyperactivation of NADPH oxidase (Nox) can induce high levels of ROS, which are strongly associated with diabetic nephropathy. This review discusses the theoretical basis for development of the Nox inhibitor as a regulator of ROS homeostasis to provide emerging therapeutic opportunities for diabetic nephropathy.

Funder

National Research Foundation of Korea

Ministry of Health and Welfare

Publisher

The Korean Society of Nephrology

Subject

Urology,Nephrology

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