INTERACTION BETWEEN FOOD SUPPLEMENTS AND DRUGS USING MOLECULAR DOCKING

Abstract

This study aims to reveal significant interactions between dietary supplements and pharmaceuticals (Imatinib) with the CYP3A4 receptor using the HEX 8.0 docking program. Binding energy serves as a metric for gauging the strength and stability of these interactions. In the case of Imatinib, a robust connection with CYP3A4 is observed, while associations with Naringin and Naringenin result in decreased binding energy, signifying heightened drug metabolism in the presence of these supplements. These findings underscore the critical importance of comprehending food-drug interactions and the potential adjustments in systemic bioavailability and drug pharmacokinetics. Interactions with CYP3A4 can significantly impact treatment efficacy and safety. Factors such as dietary habits and supplement intake can influence these interactions. Consequently, a comprehensive understanding and vigilant monitoring of these dynamics are imperative to ensure appropriate and safe therapeutic regimens.